A comparison of regression interval mapping and multiple interval mapping for linked QTL
نویسندگان
چکیده
منابع مشابه
QTL Analysis using Bayesian Interval Mapping
R/qtlbim (www.qtlbim.org) provides a powerful suite of tools for model selection of the genetic architecture for traits influenced by multiple quantitative trait loci (QTL). The Markov chain Monte Carlo (MCMC) sampling approach draws samples from the more probable genetic architectures. Subsequent visualization and summary provides posterior estimates of the number and location of QTL, their ma...
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A general method is proposed for calculating approximate thresholds of interval mapping tests for quantitative trait loci (QTL) detection. Simulation results show that this method, when applied to backcross and F2 populations, gives good approximations and is useful for any situation. Programs which calculate these thresholds for backcross, recombinant inbreds and F2 for any given level and any...
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A new statistical method for mapping quantitative trait loci (QTL), called multiple interval mapping (MIM), is presented. It uses multiple marker intervals simultaneously to fit multiple putative QTL directly in the model for mapping QTL. The MIM model is based on Cockerham's model for interpreting genetic parameters and the method of maximum likelihood for estimating genetic parameters. With t...
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Many statistical methods have been developed to map multiple quantitative trait loci (QTL) in experimental cross populations. Among these methods, multiple-interval mapping (MIM) can map QTL with epistasis simultaneously. However, the previous implementation of MIM is for continuously distributed traits. In this study we extend MIM to ordinal traits on the basis of a threshold model. The method...
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ژورنال
عنوان ژورنال: Heredity
سال: 2005
ISSN: 0018-067X,1365-2540
DOI: 10.1038/sj.hdy.6800667